The Inception of Insulin Potentiation Therapy Low Dose

Insulin Potentiation Therapy (IPT) was initially developed in 1930 for the treatment of human disease by Donato Perez Garcia, Sr. MD (1896-1971). A surgeon lieutenant in the Mexican military establishment, his preliminary work with insulin involved an innovative course of self-treatment for a gastrointestinal problem that he suffered from for years. All previous treatments had failed to resolve it.

When he first learned of the then newly discovered hormone insulin being used to treat diabetes, he noted that, in addition to diabetes, its use was also indicated for the treatment of non-diabetic malnutrition. So he decided to try it on himself. The treatment was completely successful; his symptoms disappeared and his weight became normal.

Reflecting on his own experience, Dr. Perez Garcia did what many innovators in the medical field do: he asked himself "why?" He considered that the insulin might have helped his body tissues assimilate the food he had eaten and wondered if perhaps insulin might help tissues assimilate medications.

This led to the unique technique that Drs. Donato Perez Garcia, Jr., MD, his son Donato Perez Garcia III, MD and Steven G. Ayre, MD eventually developed to treat cancer. The technique became known as Insulin Potentiation Therapy, commonly referred to today as IPT. While IPT can be used to treat and manage a variety of diseases, its application in cancer management is particularly ingenious. These physicians recognized the possibility that giving cancer cells insulin would prime cell membranes to open up. Coordinating this event with the introduction of low-dose chemotherapy, it is believed that much more of the chemotherapy drugs are able to get inside the cancer cells to kill them. At the same time, healthy cells are left unharmed. This process allows patients to avoid the worst of the dangerous and undesirable side effects caused by traditional, higher-dosage chemotherapy treatments.

First Clinical Use of IPT

Dr. Perez Garcia first performed IPT on a patient in 1930. Carlos Sosa had neurosyphilis, an illness that affects the brain and was, at the time, considered incurable. Using salts of mercury and arsenic (standard treatment for syphilis then) in combination with insulin, Dr. Perez Garcia achieved a radical cure for Mr. Sosa (penicillin and other antibiotics that would eventually be used to treat syphilis did not appear until after 1940). In the newspaper El Universal (January 14, 1930), Mr. Sosa told a reporter about his suffering and his remarkable recuperation. He lived until the late 1970s.

The World Takes Notice

In 1937, Dr. Perez Garcia was invited to the United States to demonstrate his therapy at the Austin State Hospital in Austin, Texas, and at St. Elizabeth's Hospital in Washington, D.C. Upon his return to Mexico, Dr. Perez Garcia managed a military medical clinic where he produced powerful clinical results in significant numbers of his patients with applications of his IPT™ therapy.

In 1943, the doctor was invited to treat some patients at the San Diego Naval Hospital, where he affected more of the same positive changes in patients suffering from neurosyphilis, malaria, rheumatic fever, and cholecystitis. The results led to a write-up of Dr. Perez Garcia and his "insulin treatments" in the April 10, 1944 edition of TIME magazine, titled “Insulin for Everything”’.

Trio of Medical Doctors Develop IPT in the Scientific Medical Community

Donato Perez Garcia, Jr., MD and his son Donato Perez Garcia III, MD followed in the developer's footsteps, both learning and practicing IPT™ in Mexico. A third doctor, Steven G. Ayre, MD became caught up in the enthusiasm and promise surrounding this treatment technique and visited Dr. Donato Perez Garcia Jr's Mexico City clinic in the summer of 1976 to receive training in IPT™. Since that summer, Dr. Ayre has worked closely with the Drs. Donato Perez Garcia over the following decades to develop IPT™ through trials and research, writing five peer-reviewed scientific journal articles and making several presentations in an effort to develop IPT™ through many studies and trials.

One such presentation occurred in 1996 when Drs. Donato Perez Garcia, Jr. and Steven G. Ayre presented IPT™ at the 42nd Annual Symposium on Fundamental Cancer Research held at the prestigious M.D. Anderson Institute in Houston, Texas. In response to the winds of change, the institute set up its own Center for Alternative Medicine Research. Motivated by the compelling clinical evidence presented at this 1996 Symposium, investigators associated with that institution undertook a first hand look at the "Mexican - Insulin Potentiation Therapy." After reviewing the clinical evidence gathered through Dr. Donato Garcia Perez Jr's clinic in Mexico City and Dr. Donato Garcia Perez III's clinic in Tijuana, the investigator who performed the site visits at both clinics remarked, "This is incredible. How come nothing has ever been done about this before?"

Due to the concerted efforts of people at the MD Anderson Institute, an invitation was extended to the trio of IPT™ doctors to present the scientific background on IPT™, including some case presentations from the clinical work done in Mexico. This presentation was made at the National Institutes of Health, Office of Alternative Medicine POMES conference in August of 1997.

Another invitation was extended to Drs. Perez Garcia, Jr. and Ayre to make a Best Case Series presentation before the members of the Cancer Advisory Panel of the Office of Complementary and Alternative Medicine at the National Institutes of Health in Bethesda, Maryland. Drs. Ayre and Perez Garcia, Jr. made this presentation on September 18, 2000. The Panel members were impressed with the cases presented, however it was claimed that there was insufficient data to warrant any action to formally study IPT™ at that time. The IPT™ physicians were counseled to produce more prospective treatment data and to make another Best Case Series presentation in the future. This work is now underway.

The Status of IPT Today

During the 78-year development of Insulin Potentiation Therapy, those who have administered it and documented its use have held the conviction that the therapy is valuable, and that knowledge of it should be made widely available to the medical profession. But, as IPT™'s proponents have learned, "you can't push the river." It became clear to them that the way to accomplish their goals is to work quietly and diligently, treating those patients who ask for help, documenting all results, publishing these results in medical journals, and develop, as funding permits, more sophisticated clinical trials. The Drs. Perez Garcia and Dr. Ayre have learned that "the river will flow, ceaselessly, at its own pace." But they take comfort in knowing that the river is always changing course.

French
Spanish